Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches
Anil K. Philip, Betty Philip
Philip AK, et al. OMJ. 25, 70-78 (2010); doi:10.5001/omj.2010.24
ABSTRACT
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.
Department of Pharmaceutics, School of Pharmacy, University of Nizwa, Birkat Al Mouz, Nizwa-616, Sultanate of Oman.
Received: 07 Feb 2010
Accepted: 14 Mar 2010
Address correspondence and reprint request to: Dr. Anil K. Philip, Assistant Professor Department of Pharmaceutics, School of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Birkat Al Mouz, Nizwa-616, Sultanate of Oman.
E-mail: philip@unizwa.edu.om, philipanil23@yahoo.co.in
Philip AK, et al. OMJ. 25, 70-78 (2010); doi:10.5001/omj.2010.24